FZD9

Frizzled family receptor 9
Identifiers
Symbols	FZD9; CD349; FZD3
External IDs	OMIM: 601766 MGI: 1313278 HomoloGene: 2619 IUPHAR: FZD9 GeneCards: FZD9 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • Wnt-protein binding • PDZ domain binding • protein homodimerization activity • Wnt-activated receptor activity • protein heterodimerization activity Cellular component • cytoplasm • plasma membrane • cell surface • integral to membrane • filopodium membrane • perinuclear region of cytoplasm Biological process • vasculature development • nervous system development • neuroblast proliferation • brain development • learning or memory • gonad development • embryo development • B cell differentiation • canonical Wnt receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8326	14371
Ensembl	ENSG00000188763	ENSMUSG00000049551
UniProt	O00144	Q9R216
RefSeq (mRNA)	NM_003508.2	NM_010246.1
RefSeq (protein)	NP_003499.1	NP_034376.1
Location (UCSC)	Chr 7: 72.85 – 72.85 Mb	Chr 5: 135.25 – 135.25 Mb
PubMed search	[1]	[2]

Frizzled-9 is a protein that in humans is encoded by the FZD9 gene. FZD9 has also been designated as CD349 (cluster of differentiation 349).

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.

See also

• Frizzled

Further reading

• Datta DV (1977). "Viral hepatitis (Chandigarh study)". The Journal of the Association of Physicians of India 25 (5): 325–30. PMID 914765.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21233/.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21479/.
• Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (2002). "Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling". J. Biol. Chem. 277 (40): 37479–86. doi:10.1074/jbc.M205658200. PMID 12138115.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Winn RA, Marek L, Han SY, et al. (2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". J. Biol. Chem. 280 (20): 19625–34. doi:10.1074/jbc.M409392200. PMID 15705594.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Winn RA, Van Scoyk M, Hammond M, et al. (2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". J. Biol. Chem. 281 (37): 26943–50. doi:10.1074/jbc.M604145200. PMID 16835228.

External links

• "Frizzled Receptors: FZD₉". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3067.
• FZD9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.