CELSR3

Cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
Identifiers
Symbols	CELSR3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2; RESDA1
External IDs	OMIM: 604264 MGI: 1858236 HomoloGene: 1077 IUPHAR: CELSR3 GeneCards: CELSR3 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • calcium ion binding • protein binding Cellular component • plasma membrane • integral to membrane Biological process • neuron migration • homophilic cell adhesion • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • axonal fasciculation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1951	107934
Ensembl	ENSG00000008300	ENSMUSG00000023473
UniProt	Q9NYQ7	Q91ZI0
RefSeq (mRNA)	NM_001407.2	NM_080437.2
RefSeq (protein)	NP_001398.2	NP_536685.2
Location (UCSC)	Chr 3: 48.67 – 48.7 Mb	Chr 9: 108.83 – 108.85 Mb
PubMed search	[1]	[2]

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.

See also

• Flamingo (protein)

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726. //www.ncbi.nlm.nih.gov/pmc/articles/PMC16203/.
• Formstone CJ, Barclay J, Rees M, Little PF (2000). "Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9". Mamm. Genome 11 (5): 392–4. doi:10.1007/s003350010073. PMID 10790539.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. //www.ncbi.nlm.nih.gov/pmc/articles/PMC187542/.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.