FZD7

Frizzled family receptor 7
Identifiers
Symbols	FZD7; FzE3
External IDs	OMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: FZD7 GeneCards: FZD7 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • Wnt-protein binding • PDZ domain binding • Wnt-activated receptor activity Cellular component • cytoplasm • plasma membrane • integral to membrane • neuron projection membrane • apical part of cell Biological process • vasculature development • regulation of transcription, DNA-dependent • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • Wnt receptor signaling pathway, calcium modulating pathway • axonogenesis • brain development • gonad development • negative regulation of cell-substrate adhesion • satellite cell maintenance involved in skeletal muscle regeneration • stem cell maintenance • neuron differentiation • T cell differentiation in thymus • substrate adhesion-dependent cell spreading • regulation of catenin import into nucleus • non-canonical Wnt receptor signaling pathway via JNK cascade • positive regulation of phosphorylation • negative regulation of ectodermal cell fate specification • positive regulation of transcription, DNA-dependent • positive regulation of JNK cascade • somatic stem cell division • positive regulation of epithelial cell proliferation involved in wound healing • canonical Wnt receptor signaling pathway • mesenchymal to epithelial transition • cellular response to retinoic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8324	14369
Ensembl	ENSG00000155760	ENSMUSG00000041075
UniProt	O75084	Q61090
RefSeq (mRNA)	NM_003507.1	NM_008057.3
RefSeq (protein)	NP_003498.1	NP_032083.3
Location (UCSC)	Chr 2: 202.9 – 202.9 Mb	Chr 1: 59.48 – 59.49 Mb
PubMed search	[1]	[2]

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

Interactions

FZD7 has been shown to interact with DLG4.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₇". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065.

Further reading

• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21233/.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Vincan E, Darcy PK, Farrelly CA, et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
• Struewing IT, Barnett CD, Zhang W, et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.