CD97

CD97 molecule
PDB rendering based on 2bo2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2bo2, 2bou, 2box
Identifiers
Symbols	CD97; TM7LN1
External IDs	OMIM: 601211 MGI: 1347095 HomoloGene: 8050 IUPHAR: CD97 GeneCards: CD97 Gene
Gene Ontology Molecular function • transmembrane signaling receptor activity • G-protein coupled receptor activity • calcium ion binding Cellular component • extracellular space • plasma membrane • integral to plasma membrane Biological process • cellular component movement • inflammatory response • immune response • cell adhesion • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • cell-cell signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	976	26364
Ensembl	ENSG00000123146	ENSMUSG00000002885
UniProt	P48960	Q9Z0M6
RefSeq (mRNA)	NM_001025160.2	NM_001163029.1
RefSeq (protein)	NP_001020331.1	NP_001156501.1
Location (UCSC)	Chr 19: 14.49 – 14.52 Mb	Chr 8: 83.72 – 83.74 Mb
PubMed search	[1]	[2]

CD97 antigen is a protein that in humans is encoded by the CD97 gene.

This gene encodes a member of the adhesion-GPCR receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. In the case of CD97 the N-terminal domains consist of alternatively spliced epidermal growth factor (EGF)-like domains. These mediate binding to its cellular ligand, decay accelerating factor (DAF/CD55), a regulatory protein of the complement cascade, however the CD55-CD97 interaction is believed to have an activity independent of complement. Alternative splicing has been observed for this gene and three variants have been found.

Further reading

• Mustafa T, Klonisch T, Hombach-Klonisch S, Kehlen A, Schmutzler C, Koehrle J, Gimm O, Dralle H, Hoang-Vu C (February 2004). "Expression of CD97 and CD55 in human medullary thyroid carcinomas". Int. J. Oncol. 24 (2): 285–94. PMID 14719104. 

• Mustafa T, Eckert A, Klonisch T, Kehlen A, Maurer P, Klintschar M, Erhuma M, Zschoyan R, Gimm O, Dralle H, Schubert J, Hoang-Vu C (January 2005). "Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas". Cancer Epidemiol. Biomarkers Prev. 14 (1): 108–19. PMID 15668483. 

• Kwakkenbos MJ, Kop EN, Stacey M et al. (2004). "The EGF-TM7 family: a postgenomic view". Immunogenetics 55 (10): 655–66. doi:10.1007/s00251-003-0625-2. PMID 14647991. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Gray JX, Haino M, Roth MJ et al. (1997). "CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation". J. Immunol. 157 (12): 5438–47. PMID 8955192. 
• Hamann J, Vogel B, van Schijndel GM, van Lier RA (1997). "The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF)". J. Exp. Med. 184 (3): 1185–9. doi:10.1084/jem.184.3.1185. PMC 2192782. PMID 9064337. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2192782/. 
• Aust G, Eichler W, Laue S et al. (1997). "CD97: a dedifferentiation marker in human thyroid carcinomas". Cancer Res. 57 (9): 1798–806. PMID 9135025. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Ghannadan M, Baghestanian M, Wimazal F et al. (1998). "Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies". J. Invest. Dermatol. 111 (4): 689–95. doi:10.1046/j.1523-1747.1998.00359.x. PMID 9764855. 
• Qian YM, Haino M, Kelly K, Song WC (1999). "Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55)". Immunology 98 (2): 303–11. doi:10.1046/j.1365-2567.1999.00859.x. PMC 2326925. PMID 10540231. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2326925/. 
• Eichler W (2000). "CD97 isoform expression in leukocytes". J. Leukoc. Biol. 68 (4): 561–7. PMID 11037979. 
• Lin HH, Stacey M, Saxby C et al. (2001). "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex". J. Biol. Chem. 276 (26): 24160–9. doi:10.1074/jbc.M101770200. PMID 11297558. 
• Jaspars LH, Vos W, Aust G et al. (2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens 57 (4): 325–31. doi:10.1034/j.1399-0039.2001.057004325.x. PMID 11380941. 
• Steinert M, Wobus M, Boltze C et al. (2002). "Expression and Regulation of CD97 in Colorectal Carcinoma Cell Lines and Tumor Tissues". Am. J. Pathol. 161 (5): 1657–67. doi:10.1016/S0002-9440(10)64443-4. PMC 1850798. PMID 12414513. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1850798/. 
• Visser L, de Vos AF, Hamann J et al. (2003). "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". J. Neuroimmunol. 132 (1–2): 156–63. doi:10.1016/S0165-5728(02)00306-5. PMID 12417446. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Stacey M, Chang GW, Davies JQ et al. (2003). "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans". Blood 102 (8): 2916–24. doi:10.1182/blood-2002-11-3540. PMID 12829604. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.