CHRNB3

Cholinergic receptor, nicotinic, beta 3 (neuronal)
Identifiers
Symbol	CHRNB3
External IDs	OMIM: 118508 MGI: 106212 HomoloGene: 36035 IUPHAR: β3 ChEMBL: 2586 GeneCards: CHRNB3 Gene
Gene Ontology Molecular function • acetylcholine-activated cation-selective channel activity • channel activity • acetylcholine binding Cellular component • plasma membrane • acetylcholine-gated channel complex • integral to membrane • cell junction • postsynaptic membrane Biological process • transport • signal transduction • synaptic transmission • synaptic transmission, cholinergic Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1142	108043
Ensembl	ENSG00000147432	ENSMUSG00000031492
UniProt	Q05901	Q8BMN3
RefSeq (mRNA)	NM_000749.3	NM_027454.4
RefSeq (protein)	NP_000740.1	NP_081730.1
Location (UCSC)	Chr 8: 42.55 – 42.59 Mb	Chr 8: 27.37 – 27.4 Mb
PubMed search	[1]	[2]

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.

See also

• Nicotinic acetylcholine receptor

Further reading

• Green WN, Millar NS (1995). "Ion-channel assembly.". Trends Neurosci. 18 (6): 280–7. doi:10.1016/0166-2236(95)93915-K. PMID 7571003. 
• Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol.. Reviews of Physiology, Biochemistry and Pharmacology 147: 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266. 
• Willoughby JJ, Ninkina NN, Beech MM et al. (1993). "Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit". Neurosci. Lett. 155 (2): 136–9. doi:10.1016/0304-3940(93)90691-D. PMID 7690916. 
• Koyama K, Sudo K, Nakamura Y (1994). "Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2". Genomics 21 (2): 460–1. doi:10.1006/geno.1994.1300. PMID 8088849. 
• Elliott KJ, Ellis SB, Berckhan KJ et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. 
• Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. 
• Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. PMID 9193799. 
• Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG (1998). "A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor". J. Biol. Chem. 273 (25): 15317–20. doi:10.1074/jbc.273.25.15317. PMID 9624109. 
• Sato KZ, Fujii T, Watanabe Y et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. 
• Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes". J. Physiol. (Lond.) 529 Pt 3 (Pt 3): 565–77. PMC 2270211. PMID 11118490. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2270211/. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Boorman JP, Beato M, Groot-Kormelink PJ et al. (2004). "The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors". J. Biol. Chem. 278 (45): 44033–40. doi:10.1074/jbc.M211719200. PMID 12912995. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/. 

External links

• CHRNB3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.