GPR177

Wntless homolog (Drosophila)
Identifiers
Symbols	WLS; C1orf139; EVI; GPR177; MRP
External IDs	OMIM: 611514 MGI: 1915401 HomoloGene: 11779 GeneCards: WLS Gene
Gene Ontology Molecular function • signal transducer activity • protein binding Cellular component • Golgi membrane • integral to membrane • cytoplasmic vesicle membrane Biological process • multicellular organismal development • Wnt receptor signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of canonical Wnt receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79971	68151
Ensembl	ENSG00000116729	ENSMUSG00000028173
UniProt	Q5T9L3	Q6DID7
RefSeq (mRNA)	NM_001002292.3	NM_026582.4
RefSeq (protein)	NP_001002292.3	NP_080858.3
Location (UCSC)	Chr 1: 68.56 – 68.7 Mb	Chr 3: 159.84 – 159.94 Mb
PubMed search	[1]	[2]

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene that encodes a receptor for Wnt proteins in Wnt-secreting cells.

Wntless was recently shown to be a cargo for the retromer complex.

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Bänziger C, Soldini D, Schütt C, et al. (2006). "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.". Cell 125 (3): 509–22. doi:10.1016/j.cell.2006.02.049. PMID 16678095.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.ncbi.nlm.nih.gov/pmc/articles/PMC403697/.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.

See also

• GPR177+receptor,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.