C3a receptor

Complement component 3a receptor 1
Identifiers
Symbols	C3AR1; AZ3B; C3AR; HNFAG09
External IDs	OMIM: 605246 MGI: 1097680 HomoloGene: 2992 IUPHAR: C3a receptor ChEMBL: 4761 GeneCards: C3AR1 Gene
Gene Ontology Molecular function • complement component C3a binding • phosphatidylinositol phospholipase C activity • complement component C3a receptor activity • G-protein coupled receptor activity • C3a anaphylatoxin receptor activity Cellular component • plasma membrane • integral to plasma membrane Biological process • tolerance induction to nonself antigen • chemotaxis • inflammatory response • G-protein coupled receptor signaling pathway • elevation of cytosolic calcium ion concentration • blood circulation • regulation of blood pressure • positive regulation vascular endothelial growth factor production • positive regulation of macrophage chemotaxis • positive regulation of angiogenesis • positive regulation of neutrophil chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	719	12267
Ensembl	ENSG00000171860	ENSMUSG00000040552
UniProt	Q16581	O09047
RefSeq (mRNA)	NM_004054.2	NM_009779.2
RefSeq (protein)	NP_004045.1	NP_033909.1
Location (UCSC)	Chr 12: 8.21 – 8.22 Mb	Chr 6: 122.85 – 122.86 Mb
PubMed search	[1]	[2]

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.

Although its official name implies it only binds C3a, it also binds C4a.

Further reading

• Sim RB, Laich A (2001). "Serine proteases of the complement system". Biochem. Soc. Trans. 28 (5): 545–50. PMID 11044372.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Roglic A, Prossnitz ER, Cavanagh SL, et al. (1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochim. Biophys. Acta 1305 (1–2): 39–43. PMID 8605247.
• Ames RS, Li Y, Sarau HM, et al. (1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". J. Biol. Chem. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.
• Crass T, Raffetseder U, Martin U, et al. (1996). "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells". Eur. J. Immunol. 26 (8): 1944–50. doi:10.1002/eji.1830260840. PMID 8765043.
• Ames RS, Nuthulaganti P, Kumar C (1996). "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins". FEBS Lett. 395 (2–3): 157–9. doi:10.1016/0014-5793(96)01018-6. PMID 8898085.
• Martin U, Bock D, Arseniev L, et al. (1997). "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes". J. Exp. Med. 186 (2): 199–207. doi:10.1084/jem.186.2.199. PMC 2198980. PMID 9221749. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2198980/.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hollmann TJ, Haviland DL, Kildsgaard J, et al. (1998). "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene". Mol. Immunol. 35 (3): 137–48. doi:10.1016/S0161-5890(98)00021-2. PMID 9694514.
• Lienenklaus S, Ames RS, Tornetta MA, et al. (1998). "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor". J. Immunol. 161 (5): 2089–93. PMID 9725198.
• Davoust N, Jones J, Stahel PF, et al. (1999). "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells". Glia 26 (3): 201–11. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761.
• Settmacher B, Bock D, Saad H, et al. (1999). "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a". J. Immunol. 162 (12): 7409–16. PMID 10358194.
• Feild JA, Foley JJ, Testa TT, et al. (1999). "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15". FEBS Lett. 460 (1): 53–6. doi:10.1016/S0014-5793(99)01317-4. PMID 10571060.
• Petering H, Köhl J, Weyergraf A, et al. (2000). "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a". J. Immunol. 164 (7): 3783–9. PMID 10725738.
• Drouin SM, Kildsgaard J, Haviland J, et al. (2001). "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma". J. Immunol. 166 (3): 2025–32. PMID 11160252.
• Ames RS, Lee D, Foley JJ, et al. (2001). "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models". J. Immunol. 166 (10): 6341–8. PMID 11342658.
• Kirchhoff K, Weinmann O, Zwirner J, et al. (2001). "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin". Immunology 103 (2): 210–7. doi:10.1046/j.1365-2567.2001.01197.x. PMC 1783227. PMID 11412308. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1783227/.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Reca R, Mastellos D, Majka M, et al. (2003). "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1". Blood 101 (10): 3784–93. doi:10.1182/blood-2002-10-3233. PMID 12511407.

External links

• "Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2973.
• C3AR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)