GPR65

G protein-coupled receptor 65
Identifiers
Symbols	GPR65; TDAG8; hTDAG8
External IDs	OMIM: 604620 MGI: 108031 HomoloGene: 2675 IUPHAR: GPR65 GeneCards: GPR65 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity Cellular component • plasma membrane • integral to plasma membrane Biological process • apoptotic process • immune response • G-protein coupled receptor signaling pathway • multicellular organismal development • response to acidity • positive regulation of cAMP biosynthetic process • actin cytoskeleton reorganization • activation of Rho GTPase activity • positive regulation of stress fiber assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8477	14744
Ensembl	ENSG00000140030	ENSMUSG00000021886
UniProt	Q8IYL9	Q61038
RefSeq (mRNA)	NM_003608.3	NM_008152.2
RefSeq (protein)	NP_003599.2	NP_032178.1
Location (UCSC)	Chr 14: 88.47 – 88.48 Mb	Chr 12: 98.27 – 98.28 Mb
PubMed search	[1]	[2]

Psychosine receptor is a protein that in humans is encoded by the GPR65 gene.

See also

• Proton-sensing G protein-coupled receptors

Further reading

• Im DS, Heise CE, Nguyen T, et al. (2001). "Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation". J. Cell Biol. 153 (2): 429–34. doi:10.1083/jcb.153.2.429. PMC 2169470. PMID 11309421. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2169470/.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Sin WC, Zhang Y, Zhong W, et al. (2004). "G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers". Oncogene 23 (37): 6299–303. doi:10.1038/sj.onc.1207838. PMID 15221007.
• Wang JQ, Kon J, Mogi C, et al. (2004). "TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor". J. Biol. Chem. 279 (44): 45626–33. doi:10.1074/jbc.M406966200. PMID 15326175.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Ishii S, Kihara Y, Shimizu T (2005). "Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor". J. Biol. Chem. 280 (10): 9083–7. doi:10.1074/jbc.M407832200. PMID 15618224.
• Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. doi:10.1073/pnas.0409415102. PMC 545089. PMID 15665078. //www.ncbi.nlm.nih.gov/pmc/articles/PMC545089/.