GPRC6A
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| G protein-coupled receptor, family C, group 6, member A | ||||||||
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| Identifiers | ||||||||
| Symbols | GPRC6A; GPCR; bA86F4.3 | |||||||
| External IDs | OMIM: 613572 MGI: 2429498 HomoloGene: 17529 IUPHAR: GPRC6 GeneCards: GPRC6A Gene | |||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 222545 | 210198 | ||||||
| Ensembl | ENSG00000173612 | ENSMUSG00000019905 | ||||||
| UniProt | Q5T6X5 | Q8K4Z6 | ||||||
| RefSeq (mRNA) | NM_148963.2 | NM_153071.1 | ||||||
| RefSeq (protein) | NP_683766.2 | NP_694711.1 | ||||||
| Location (UCSC) | Chr 6: 117.11 – 117.15 Mb |
Chr 10: 51.61 – 51.63 Mb |
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| PubMed search | [1] | [2] | ||||||
G-protein coupled receptor family C group 6 member A is a protein that in humans is encoded by the GPRC6A gene.[1] This receptor functions as a sensor of L-amino acids,[2] osteocalcin,[3] and steroids.[4]
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[edit] Clinical significance
GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediated rapid, non-genomic prostate cancer cell responses to testosterone.[5]
[edit] References
- ^ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=222545.
- ^ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
- ^ Pi M, Wu Y, Quarles LD (July 2011). "GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo". J. Bone Miner. Res. 26 (7): 1680–3. doi:10.1002/jbmr.390. PMID 21425331.
- ^ Pi M, Parrill AL, Quarles LD (December 2010). "GPRC6A mediates the non-genomic effects of steroids". J. Biol. Chem. 285 (51): 39953–64. doi:10.1074/jbc.M110.158063. PMID 20947496.
- ^ Pi M, Quarles LD (June 2011). "GPRC6A regulates prostate cancer progression". Prostate 72 (4): 399–409. doi:10.1002/pros.21442. PMID 21681779.
[edit] Further reading
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor". Gene 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188.
- Wellendorph P, Hansen KB, Balsgaard A, et al. (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
- Pi M, Faber P, Ekema G, et al. (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1435382/.
[edit] External links
- GPRC6A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Calcium-Sensing Receptors: GPRC6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2968.
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