5-HT1D receptor

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Identifiers
Symbols	HTR1D; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
External IDs	OMIM: 182133 MGI: 96276 HomoloGene: 20240 IUPHAR: 5-HT1D ChEMBL: 1983 GeneCards: HTR1D Gene
Gene Ontology Molecular function • serotonin receptor activity • serotonin binding Cellular component • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • synaptic transmission • response to toxin • intestine smooth muscle contraction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3352	15552
Ensembl	ENSG00000179546	ENSMUSG00000070687
UniProt	P28221	Q61224
RefSeq (mRNA)	NM_000864.4	NM_008309.4
RefSeq (protein)	NP_000855.1	NP_032335.2
Location (UCSC)	Chr 1: 23.52 – 23.52 Mb	Chr 4: 136.42 – 136.44 Mb
PubMed search	[1]	[2]

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT_1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.

Ligands

Agonists

• 5-(Nonyloxy)tryptamine,
• sumatriptan (vasoconstrictor in migraine)
• 5-Carboxamidotryptamine (5-CT)
• 5-(t-Butyl)-N-methyltryptamine
• CP-135,807
• CP-286,601
• PNU-109,291 ((S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide)
• PNU-142,633 ((1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide)
• GR-46611 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
• L-694,247 (2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine)
• L-772,405

Antagonists

• Ziprasidone (atypical antipsychotic) [3]
• methiothepin (antipsychotic)
• yohimbine (aphrodisiac)
• metergoline
• ergotamine (vasoconstrictor in migraine)
• BRL-15572
• GR-127,935 (mixed 5-HT_1B/1D antagonist)
• LY-310,762
• LY-367,642
• LY-456,219
• LY-456,220

See also

• 5-HT₁ receptor
• 5-HT receptor

External links

• "5-HT_1D". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2314. 

Further reading

• Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.". Biochem. Biophys. Res. Commun. 184 (2): 752–9. doi:10.1016/0006-291X(92)90654-4. PMID 1315531. 
• Weinshank RL, Zgombick JM, Macchi MJ, et al. (1992). "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3630–4. doi:10.1073/pnas.89.8.3630. PMC 48922. PMID 1565658. //www.ncbi.nlm.nih.gov/pmc/articles/PMC48922/. 
• Hamblin MW, Metcalf MA (1991). "Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.". Mol. Pharmacol. 40 (2): 143–8. PMID 1652050. 
• Libert F, Passage E, Parmentier M, et al. (1992). "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.". Genomics 11 (1): 225–7. doi:10.1016/0888-7543(91)90125-X. PMID 1662665. 
• Libert F, Parmentier M, Lefort A, et al. (1989). "Selective amplification and cloning of four new members of the G protein-coupled receptor family.". Science 244 (4904): 569–72. doi:10.1126/science.2541503. PMID 2541503. 
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
• Salim K, Fenton T, Bacha J, et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation.". J. Biol. Chem. 277 (18): 15482–5. doi:10.1074/jbc.M201539200. PMID 11854302. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Bergen AW, van den Bree MB, Yeager M, et al. (2004). "Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.". Mol. Psychiatry 8 (4): 397–406. doi:10.1038/sj.mp.4001318. PMID 12740597. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Li J, Zhang X, Wang Y, et al. (2007). "The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (8): 874–6. doi:10.1002/ajmg.b.30364. PMID 17099886. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.