Linopirdine

Linopirdine
Systematic (IUPAC) name
	1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	105431-72-9
ATC code	N06BX09
PubChem	CID 3932
IUPHAR ligand	2599
ChemSpider	3795
UNII	I5TB3NZ94T
KEGG	D04741
ChEMBL	CHEMBL319111
Chemical data
Formula	C26H21N3O
Mol. mass	391.465 g/mol
	SMILES O=C2N(c1ccccc1C2(Cc3ccncc3)Cc4ccncc4)c5ccccc5;
	InChI InChI=1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2 ; Key:YEJCDKJIEMIWRQ-UHFFFAOYSA-N ;
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Linopirdine is a psychostimulant/nootropic, which has neuroprotective effects.^[1]^[2] It acts as a potassium channel blocker, and releases acetylcholine, via modulation of nAChRs, which is probably responsible for its nootropic action.^[3]

[edit] See also

^ Solntseva, EI.; Bukanova, IuV.; Skrebitskiĭ, VG.. "[Memory and potassium channels].". Usp Fiziol Nauk 34 (4): 16-25. PMID 14658300.
^ Xia, S.; Lampe, PA.; Deshmukh, M.; Yang, A.; Brown, BS.; Rothman, SM.; Johnson, EM.; Yu, SP. (Jan 2002). "Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation.". J Neurosci 22 (1): 114-22. PMID 11756494. http://www.jneurosci.org/content/22/1/114.long.
^ Dzhura, EV.; He, W.; Currie, KP. (Mar 2006). "Linopirdine modulates calcium signaling and stimulus-secretion coupling in adrenal chromaffin cells by targeting M-type K+ channels and nicotinic acetylcholine receptors.". J Pharmacol Exp Ther 316 (3): 1165-74. doi:10.1124/jpet.105.095570. PMID 16280412.

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