Mesulergine
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| Systematic (IUPAC) name | |
| N'-[(8α)-1,6-dimethylergolin-8-yl)-N,N-dimethylsulfamide | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 64795-35-3  |
| ATC code | ? |
| PubChem | CID 68848 |
| IUPHAR ligand | 206 |
| ChemSpider | 62081  |
| UNII | SML95FK06I |
| ChEMBL | CHEMBL462903 |
| Chemical data | |
| Formula | C18H26N4O2S |
| Mol. mass | 362.49 g/mol |
| SMILES | eMolecules & PubChem |
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Mesulergine is a psychoactive drug of the ergoline chemical class that acts on serotonin and dopamine receptors.[1][2]
The compound had entered clinical trials for the treatment of Parkinson's disease, however further development was halted due to adverse histological abnormalities in rats.[3]
[edit] See also
[edit] References
- ^ Closse A (May 1983). "[3H]-Mesulergine, a selective ligand for serotonin-2 receptors". Life Sci. 32 (21): 2485–95. doi:10.1016/0024-3205(83)90375-2. PMID 6855451.
- ^ Markstein R (November 1983). "Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors". Eur. J. Pharmacol. 95 (1-2): 101–7. doi:10.1016/0014-2999(83)90272-8. PMID 6230246.
- ^ Dupont E, Mikkelsen B, Jakobsen J (April 1986). "Mesulergine in early Parkinson's disease: a double blind controlled trial". J. Neurol. Neurosurg. Psychiatr. 49 (4): 390–5. doi:10.1136/jnnp.49.4.390. PMC 1028763. PMID 3517235. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1028763.
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