5,10-Methylenetetrahydrofolate
| 5,10-Methylenetetrahydrofolate | |
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N-[4-(3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid |
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Other names
5,10-CH2-THF, |
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| Identifiers | |
| CAS number | 3432-99-3  |
| PubChem | 108194 |
| ChemSpider | 97272 |
| MeSH | 5,10-methylenetetrahydrofolate |
| ChEBI | CHEBI:20502 |
| ChEMBL | CHEMBL117348 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C20H23N7O6 |
| Molar mass | 457.44 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references |
5,10-Methylenetetrahydrofolate (5,10-CH2-THF) is the substrate used by the enzyme methylenetetrahydrofolate reductase (MTHFR)[1][2] to generate 5-methyltetrahydrofolate (5-MTHF, or levomefolic acid).
5,10-CH2-THF can also be used as a coenzyme in the biosynthesis of thymidine. More specifically it is the C1-donor in the reactions catalyzed by thymidylate synthase and thymidylate synthase (FAD). It also acts as a coenzyme in the synthesis of serine from glycine via the enzyme serine hydroxymethyl transferase.
See also[edit]
References[edit]
- ^ "Entrez Gene: MTHFR methylenetetrahydrofolate reductase (NAD(P)H)".
- ^ Födinger M, Hörl WH, Sunder-Plassmann G (2000). "Molecular biology of 5,10-methylenetetrahydrofolate reductase.". J Nephrol 13 (1): 20–33. PMID 10720211.
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