Methoxamine
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Not to be confused with methoxetamine.
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| Systematic (IUPAC) name | |
| 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 390-28-3  |
| ATC code | C01CA10 |
| PubChem | CID 6082 |
| IUPHAR ligand | 483 |
| DrugBank | DB00723 |
| ChemSpider | 5857 |
| UNII | HUQ1KC1YLI |
| KEGG | D08201 |
| ChEMBL | CHEMBL524 |
| Chemical data | |
| Formula | C11H17NO3 |
| Mol. mass | 211.258 |
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Methoxamine is an α1-adrenergic receptor agonist,[1] similar in structure to phenylephrine and 2,5-DMA. It was Developed by Burroughs-Wellcome in the 1940s.[2] The drug induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure. Because of its hypertensive effects, it may evoke a compensatory reflex bradycardia via the baroreceptors.
[edit] See also
[edit] References
- ^ Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003] "5" in Goljan, Edward F. (Paperback) Pharmacology Rapid Review (Second ed.) Philadelphia, PA: Mosby-Elsevier p. 39 ISBN 978-0-323-04550-6
- ^ US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE
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