A-372,159
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| Systematic (IUPAC) name | |
| (11S,16R)-3-[4-(propan-2-yloxy)-2-(trifluoromethyl)phenyl]-6-oxa-10,14-diazatetracyclo[8.6.1.05,17.011,16]heptadeca-1,3,5(17)-triene | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| ATC code | ? |
| ChemSpider | 9605283  |
| Chemical data | |
| Formula | C24H27F3N2O2 |
| Mol. mass | 432.478 g/mol |
| SMILES | eMolecules & PubChem |
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A-372,159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.[1]
[edit] References
- ^ Childers WE, Robichaud AJ. Recent Advances in Selective Serotonergic Agents. Annual Reports in Medicinal Chemistry 2005; Volume 40:17-33. ISBN 978-0-12-040540-4
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