SLC7A11

Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Identifiers
Symbols	SLC7A11; CCBR1; xCT
External IDs	OMIM: 607933 MGI: 1347355 HomoloGene: 22684 ChEMBL: 1075149 GeneCards: SLC7A11 Gene
Gene Ontology Molecular function • protein binding • cystine:glutamate antiporter activity Cellular component • rough endoplasmic reticulum • cytoskeleton • plasma membrane • integral to membrane Biological process • ion transport • amino acid transport • response to oxidative stress • brain development • blood coagulation • response to toxic substance • response to nicotine • leukocyte migration • transmembrane transport • lens fiber cell differentiation • platelet aggregation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23657	26570
Ensembl	ENSG00000151012	ENSMUSG00000027737
UniProt	Q9UPY5	Q9WTR6
RefSeq (mRNA)	NM_014331	NM_011990
RefSeq (protein)	NP_055146	NP_036120
Location (UCSC)	Chr 4: 139.09 – 139.16 Mb	Chr 3: 50.36 – 50.44 Mb
PubMed search	[1]	[2]

Cystine/glutamate transporter is a protein that in humans is encoded by the SLC7A11 gene.

SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.[supplied by OMIM] SLC7A11 has also been termed 'xCT', especially in older literature.

See also

• Heterodimeric amino acid transporter
• Solute carrier family

Further reading

• Bridges CC, Kekuda R, Wang H et al. (2001). "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells". Invest. Ophthalmol. Vis. Sci. 42 (1): 47–54. PMID 11133847. 
• Sato H, Tamba M, Kuriyama-Matsumura K et al. (2001). "Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-". Antioxid. Redox Signal. 2 (4): 665–71. PMID 11213471. 
• Shih AY, Murphy TH (2001). "xCt cystine transporter expression in HEK293 cells: pharmacology and localization". Biochem. Biophys. Res. Commun. 282 (5): 1132–7. doi:10.1006/bbrc.2001.4703. PMID 11302733. 
• Kim JY, Kanai Y, Chairoungdua A et al. (2001). "Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells". Biochim. Biophys. Acta 1512 (2): 335–44. doi:10.1016/S0005-2736(01)00338-8. PMID 11406111. 
• Bassi MT, Gasol E, Manzoni M et al. (2001). "Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-". Pflugers Arch. 442 (2): 286–96. doi:10.1007/s004240100537. PMID 11417227. 
• Sasaki H, Sato H, Kuriyama-Matsumura K et al. (2003). "Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression". J. Biol. Chem. 277 (47): 44765–71. doi:10.1074/jbc.M208704200. PMID 12235164. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Jiménez-Vidal M, Gasol E, Zorzano A et al. (2004). "Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway". J. Biol. Chem. 279 (12): 11214–21. doi:10.1074/jbc.M309866200. PMID 14722095. 
• Gasol E, Jiménez-Vidal M, Chillarón J et al. (2004). "Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility". J. Biol. Chem. 279 (30): 31228–36. doi:10.1074/jbc.M402428200. PMID 15151999. 
• Bridges CC, Hu H, Miyauchi S et al. (2004). "Induction of Cystine-Glutamate Transporter xc - by Human Immunodeficiency Virus Type 1 Transactivator Protein Tat in Retinal Pigment Epithelium". Invest. Ophthalmol. Vis. Sci. 45 (9): 2906–14. doi:10.1167/iovs.03-1355. PMC 2735043. PMID 15326101. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Kaleeba JA, Berger EA (2006). "Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT". Science 311 (5769): 1921–4. doi:10.1126/science.1120878. PMID 16574866. 
• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.