Perampanel

Perampanel
Systematic (IUPAC) name
	5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'H)-one
Clinical data
Pregnancy cat.	?
Legal status	Investigational
Identifiers
CAS number	380917-97-5
ATC code	N03AX22
PubChem	CID 9924495
UNII	H821664NPK
KEGG	D08964
Chemical data
Formula	C23H15N3O
Mol. mass	349.384 g/mol
SMILES	eMolecules & PubChem
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Perampanel is a drug developed by Eisai Co., which acts as a selective antagonist for the AMPA subtype of ionotropic glutamate receptors. It is being researched for several possible clinical applications including the treatment of epilepsy^[1] and Parkinson's disease.^[2]

[edit] References

^ Krauss, G. L.; Bar, M.; Biton, V.; Klapper, J. A.; Rektor, I.; Vaiciene-Magistris, N.; Squillacote, D.; Kumar, D. (2012). "Tolerability and safety of perampanel: Two randomized dose-escalation studies". Acta Neurologica Scandinavica 125 (1): 8–15. DOI:10.1111/j.1600-0404.2011.01588.x. PMID 21883097. edit
^ Gottwald MD, Aminoff MJ (July 2008). "New frontiers in the pharmacological management of Parkinson's disease". Drugs Today 44 (7): 531–45. DOI:10.1358/dot.2008.44.7.1217105. PMID 18806903.

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[0] Krauss, G. L.; Bar, M.; Biton, V.; Klapper, J. A.; Rektor, I.; Vaiciene-Magistris, N.; Squillacote, D.; Kumar, D. (2012). "Tolerability and safety of perampanel: Two randomized dose-escalation studies". Acta Neurologica Scandinavica 125 (1): 8–15. DOI:10.1111/j.1600-0404.2011.01588.x. PMID 21883097. edit

[Gottwald2008-1] Gottwald MD, Aminoff MJ (July 2008). "New frontiers in the pharmacological management of Parkinson's disease". Drugs Today 44 (7): 531–45. DOI:10.1358/dot.2008.44.7.1217105. PMID 18806903.

[1]

[2]

Perampanel

[edit] References

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