Oxycodone/paracetamol
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| Combination of | |
|---|---|
| Oxycodone | Opioid analgesic |
| Paracetamol | Anilide analgesic |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Licence data | US FDA:link |
| Pregnancy cat. | C |
| Legal status | Schedule II (US) |
| Routes | Oral |
| Identifiers | |
| CAS number | 330988-72-2  |
| ATC code | ? |
| ChemSpider | 4881971 |
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The combination oxycodone/paracetamol (North American trade name of combination Percocet, North American trade name of latter Acetaminophen) is a narcotic pain reliever used to treat moderate to severe acute (short-term) pain, marketed by Endo Pharmaceuticals.[1]
Contents |
[edit] History
The U.S. Food and Drug Administration first approved Percocet in 1976, under application ANDA 085106.[2]
[edit] Formulation
As of March 2006, Endo Pharmaceuticals produces Percocet in following dosages.[3] Percocet tablets are available in six combinations of oxycodone hydrochloride and acetaminophen, with different appearances and maximum daily doses:[3]
| Oxycodone Hydrochloride (mg) | Acetaminophen (mg) | Tablet Color | Tablet Shape | Maximum Daily Dose |
|---|---|---|---|---|
| 2.5 | 325 | pink | oval | 12 tablets |
| 5 | 325 | white | round | 12 tablets |
| 7.5 | 325 | peach | oval | 8 tablets |
| 7.5 | 500 | peach | capsule-shaped | 8 tablets |
| 10.0 | 325 | white | oblong | 6 tablets |
| 10.0 | 650 | yellow | oval | 6 tablets |
For the 2.5 mg Oxycodone HCL tablet, the usual dose is 1–2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.[3]
[edit] Use in pain management
This medicine, in recent years, has gained favor among the medical community due to its effectiveness and a lower addiction rate than morphine. It is very useful to give to someone who is experiencing acute severe pain that is neither chronic nor breakthrough.[citation needed]
[edit] Implicated in deaths
On June 30, 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[4] be limited in their sales because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to acetaminophen overdose and associated liver damage.[5]
In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.[6]
[edit] References
- ^ http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf
- ^ "Drugs@FDA. FDA approved drug products (searchable database)". U.S. Food and Drug Administration, Center for Drug Evaluation and Research. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Retrieved 2009-03-30.
- ^ a b c "Percocet oxycodone and acetaminophen tablets USP". Endo Pharmaceuticals. 2006 November. http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf. Retrieved 2009-03-30.
- ^ http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen
- ^ Harris, Gardiner (2009-07-01). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times. http://www.nytimes.com/2009/07/01/health/01fda.html?em. Retrieved 2010-05-22.
- ^ sciencedaily.com
[edit] External links
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