Iproniazid

Iproniazid

Systematic (IUPAC) name
N'-isopropylisonicotinohydrazide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
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Pharmacokinetic data
Bioavailability	?
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Identifiers
CAS number	54-92-2 Y
ATC code	N06AF05
PubChem	CID 3748
DrugBank	DB04818
ChemSpider	3617 Y
UNII	D892HFI3XA Y
KEGG	D02579 Y
ChEMBL	CHEMBL92401 Y
Chemical data
Formula	C9H13N3O
Mol. mass	179.219
SMILES	eMolecules & PubChem
InChI InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13) Y Key:NYMGNSNKLVNMIA-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Iproniazid (Euphozid, Iprazid, Ipronid, Ipronin, Marsilid, Rivivol) is a hydrazine drug used as an antidepressant. It acts as an irreversible and nonselective monoamine oxidase inhibitor (MAOI). Though it has been widely discontinued in most of the world, it is still used in France.

History

Iproniazid was the first antidepressant ever marketed. Originally intended for the treatment of tuberculosis. In 1952, its antidepressant properties were discovered when researchers noted that the patients given isoniazid became "inappropriately happy". Subsequently N-isopropyl addition lead to development as an antidepressant and was approved for use in 1958. It was later withdrawn in 1961 due to the unacceptable incidence of hepatitis and was replaced by less hepatotoxic drugs like isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).

See also

• Hydrazine (Antidepressant)