A reuptake enhancer (RE), also sometimes referred to as a reuptake activator, is a type of drug which enhances the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to a decrease in the extracellular concentrations of the neurotransmitter and therefore a decrease in neurotransmission.
Tianeptine (Stablon), a selective serotonin reuptake enhancer (SSRE), is currently the only reuptake enhancer known.
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