Pargyline
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| Systematic (IUPAC) name | |
| N-Benzyl-N-methylprop-2-yn-1-amine | |
| Clinical data | |
| MedlinePlus | a682088 |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 555-57-7  |
| ATC code | C02KC01 C02LL01 |
| PubChem | CID 4688 |
| DrugBank | DB01626 |
| ChemSpider | 4526 |
| UNII | 9MV14S8G3E |
| ChEMBL | CHEMBL673 |
| Chemical data | |
| Formula | C11H13N |
| Mol. mass | 159.23 g/mol |
| SMILES | eMolecules & PubChem |
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Pargyline (Eutonyl) is an irreversible monoamine oxidase B (MAO-B) inhibitor.[1] It has antihypertensive effects.[2]
[edit] Pharmacology
It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.[3]
[edit] References
- ^ Murphy DL, Karoum F, Pickar D, et al. (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". J. Neural Transm. Suppl. 52: 39–48. PMID 9564606.
- ^ Fuentes JA, Ordaz A, Neff NH (July 1979). "Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats". Eur. J. Pharmacol. 57 (1): 21–7. doi:10.1016/0014-2999(79)90099-2. PMID 477738.
- ^ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006
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