Mesembrine
| Mesembrine | |
|---|---|
 |
 |
|
(3aS,7aR)-3a- (3,4-dimethoxyphenyl)- 1-methyl-2,3,4,5,7,7a- hexahydroindol-6-one |
|
| Identifiers | |
| CAS number | 468-53-1  |
| PubChem | 193296 |
| ChemSpider | 167737 |
| Jmol-3D images | Image 1 |
|
|
|
|
| Properties | |
| Molecular formula | C17H23NO3 |
| Molar mass | 289.37 g mol−1 |
| log P | 1.1 |
| Supplementary data page | |
| Structure and properties |
n, εr, etc. |
| Thermodynamic data |
Phase behaviour Solid, liquid, gas |
| Spectral data | UV, IR, NMR, MS |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
|
| Infobox references |
Mesembrine is an alkaloid present in Sceletium tortuosum (kanna).[1] It has been shown to act as a serotonin reuptake inhibitor, and more recently, has also been found to behave as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4).[2] As such, mesembrine may contribute to the antidepressant effects of kanna.[3]
[edit] References
- ^ Smith MT, Crouch NR, Gericke N, Hirst M (March 1996). "Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review". Journal of Ethnopharmacology 50 (3): 119–30. PMID 8691846.
- ^ Harvey, A. L.; Young, L. C.; Viljoen, A. M.; Gericke, N. P. (October 2011). "Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids". Journal of Ethnopharmacology 137 (3): 1124–1129. doi:10.1016/j.jep.2011.07.035. PMID 21798331.
- ^ Stafford GI, Pedersen ME, van Staden J, Jäger AK (October 2008). "Review on plants with CNS-effects used in traditional South African medicine against mental diseases". Journal of Ethnopharmacology 119 (3): 513–37. doi:10.1016/j.jep.2008.08.010. PMID 18775771. http://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00449-2.
|
