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Caroxazone

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Caroxazone
Systematic (IUPAC) name
2-(2-oxo-4H-1,3-benzoxazin-3-yl)acetamide
Clinical data
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes Oral
Identifiers
CAS number 18464-39-6
ATC code None
PubChem CID 29083
ChemSpider 27057
UNII 807N226MNL YesY
Chemical data
Formula C10H10N2O3 
Mol. mass 206.20 g/mol
SMILES eMolecules & PubChem

Caroxazone (Surodil, Timostenil) is an antidepressant which was formerly used for the treatment of depression but is now no longer marketed.[1][2] It acts as a reversible monoamine oxidase inhibitor (MAOI) of both MAO-A and MAO-B subtypes, with five-fold preference for the latter.[3][4][5][6][7]

[edit] See also

[edit] References

  1. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. http://books.google.com/books?id=zNZfxR-CsYcC&lpg=PA1254&dq=caroxazone&as_brr=3&pg=PA1254#v=onepage&q=&f=false. 
  2. ^ Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A (1978). "A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline". The Journal of International Medical Research 6 (5): 388–94. PMID 359383. 
  3. ^ Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. ISBN 0-8247-9082-0. http://books.google.com/books?id=kJP3f9YKSrUC&lpg=PA56&ots=XKfRcAphTU&dq=caroxazone%20%22MAO-A%22&pg=PA56#v=onepage&q=&f=false. 
  4. ^ Moretti A, Caccia C, Martini A, et al. (May 1981). "Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers". British Journal of Clinical Pharmacology 11 (5): 511–5. PMC 1401585. PMID 7272163. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1401585. 
  5. ^ Moretti A, Caccia C, Calderini G, Menozzi M, Amico A (October 1981). "Studies on the mechanism of action of caroxazone, a new antidepressant drug". Biochemical Pharmacology 30 (19): 2728–31. doi:10.1016/0006-2952(81)90549-9. PMID 6170295. 
  6. ^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A (June 1981). "Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man". British Journal of Clinical Pharmacology 11 (6): 611–5. PMC 1402186. PMID 7272178. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1402186. 
  7. ^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E (June 1981). "Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man". British Journal of Clinical Pharmacology 11 (6): 605–10. PMC 1402193. PMID 7272177. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1402193. 
GABAA PAMs
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α2δ VDCC Blockers
5-HT1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane
H1 Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine
CRH1 Antagonists
NK2 Antagonists
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
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M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)
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