GPR64
From Wikipedia, the free encyclopedia
| G protein-coupled receptor 64 | ||||||||
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| Identifiers | ||||||||
| Symbols | GPR64; EDDM6; HE6; TM7LN2 | |||||||
| External IDs | OMIM: 300572 MGI: 2446854 HomoloGene: 4208 IUPHAR: GPR64 GeneCards: GPR64 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 10149 | 237175 | ||||||
| Ensembl | ENSG00000173698 | ENSMUSG00000031298 | ||||||
| UniProt | Q8IZP9 | Q8CJ12 | ||||||
| RefSeq (mRNA) | NM_001079858.2 | NM_001079847.1 | ||||||
| RefSeq (protein) | NP_001073327.1 | NP_001073316.1 | ||||||
| Location (UCSC) | Chr X: 19.01 – 19.14 Mb |
Chr X: 160.39 – 160.5 Mb |
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| PubMed search | [1] | [2] | ||||||
G-protein coupled receptor 64 Is a protein that in humans is encoded by the GPR64 gene. The gene product is a member of the It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [1] [2] [3] [4][5][6]
[edit] References
- ^ Yona, Stacey (2011). Adhesion-GPCRs. 1-200: Springer. ISBN 978-1-4419-7912-4.
- ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ^ Araç, D; Boucard, AA; Bolliger, MF; Nguyen, J; Soltis, SM; Südhof, TC; Brunger, AT (2012 Feb 14). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.". The EMBO journal 31 (6): 1364-78. PMID 22333914.
- ^ Kirchhoff C, Osterhoff C, Pera I, Schroter S (Jan 1999). "Function of human epididymal proteins in sperm maturation". Andrologia 30 (4–5): 225–32. doi:10.1111/j.1439-0272.1998.tb01164.x. PMID 9739419.
- ^ Osterhoff C, Ivell R, Kirchhoff C (Jun 1997). "Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily". DNA Cell Biol 16 (4): 379–89. doi:10.1089/dna.1997.16.379. PMID 9150425.
- ^ "Entrez Gene: GPR64 G protein-coupled receptor 64". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10149.
[edit] Further reading
- Obermann H, Samalecos A, Osterhoff C, et al. (2003). "HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia". Mol. Reprod. Dev. 64 (1): 13–26. doi:10.1002/mrd.10220. PMID 12420295.
- {{cite journal | author=Olsen JV, Blagoev B, Gnad F, et al. |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
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