Benzydamine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | B2 (AU) |
| Legal status | OTC(UK) |
| Routes | Oral, topical |
| Pharmacokinetic data | |
| Protein binding | <20% |
| Half-life | 13 hours |
| Excretion | Renal |
| Identifiers | |
| CAS number | 642-72-8  |
| ATC code | A01AD02 G02CC03 M01AX07 M02AA05 |
| PubChem | CID 12555 |
| ChemSpider | 12036 |
| UNII | 4O21U048EF |
| KEGG | D07516 |
| ChEMBL | CHEMBL12610 |
| Chemical data | |
| Formula | C19H23N3O |
| Mol. mass | 309.405 g/mol |
| SMILES | eMolecules & PubChem |
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Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.[1]
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[edit] Medical use
- Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy.
- Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis.
It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.
In some markets, the drug is supplied as an over-the-counter cream (Lonol in Mexico from Boehringer Ingelheim) used for topical treatment of musculoskeletal system disorders: sprains, strains, bursitis, tendinitis, synovitis, myalgia, periarthritis.
[edit] Contraindications
There are no contraindications to the use of Benzydamine except for known hypersensitivity.
[edit] Side effects
Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur.
[edit] Pharmacology
It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) and is normally free of adverse systemic effects. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.[2]
[edit] Recreational use
Benzydamine has been misused recreationally. In overdosages it acts a deliriant and CNS stimulant.[2] Such misuse, particularly among teenagers, has been reported in Poland,[2] Brazil[3][4] and Romania.
[edit] See also
[edit] References
- ^ Turnbull, R. S. (1995). "Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions". Journal (Canadian Dental Association) 61 (2): 127–134. PMID 7600413.
- ^ a b c Anand, J. S.; Lukasik–Glębocka, M.; Korolkiewicz, R. P. (2007). "Letter to the Editor: Recreational abuse with benzydamine hydrochloride (tantum rosa)". Clinical Toxicology 45 (2): 198–199. doi:10.1080/15563650600981210. PMID 17364645.
- ^ Opaleye, E. S.; Noto, A. R.; Sanchez, Z. M.; Moura, Y. G.; Galduróz, J. C.; Carlini, E. A. (2009). "Recreational use of benzydamine as a hallucinogen among street youth in Brazil". Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 31 (3): 208–213. doi:10.1590/S1516-44462009000300005. PMID 19784487. http://dx.doi.org/10.1590/S1516-44462009000300005.
- ^ Mota, D. M.; Costa, A. A.; Teixeira, C. D. S.; Bastos, A. A.; Dias, M. F. (2010). "Use abusive of benzydamine in Brazil: An overview in pharmacovigilance" (in portuguese). Ciencia & saude coletiva 15 (3): 717–724. doi:10.1590/S1413-81232010000300014. PMID 20464184. http://dx.doi.org/10.1590/S1413-81232010000300014.
[edit] External links
- "Benzydamine oral rinse". Medicinenet. http://www.medicinenet.com/benzydamine-oral_rinse/article.htm.
- "Difflam spray (benzydamine)". Net Doctor, UK. http://www.netdoctor.co.uk/medicines/100003456.html.
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