FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
	; PDB rendering based on 1e4j.
Available structures
PDB	1e4j, 1e4k, 1fnl, 1iis, 1iix, 1t83, 1t89
Identifiers
Symbols	FCGR3A; CD16; CD16a; FCG3; FCGR3; IGFR3
External IDs	OMIM: 146740 MGI: 2179523 HomoloGene: 477 GeneCards: FCGR3A Gene
Gene Ontology
Molecular function	• receptor activity; • IgG binding;
Cellular component	• plasma membrane; • integral to membrane;
Biological process	• immune response;
Orthologs

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Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.^[1]^[2]

[edit] References

^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
^ "Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2214.

[edit] Further reading

Anderson P, Caligiuri M, O'Brien C, et al. (1990). "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells.". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2274–8. doi:10.1073/pnas.87.6.2274. PMID 2138330.
Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23.". Immunogenetics 32 (3): 183–6. doi:10.1007/BF02114971. PMID 2146219.
Ory PA, Clark MR, Kwoh EE, et al. (1989). "Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils.". J. Clin. Invest. 84 (5): 1688–91. doi:10.1172/JCI114350. PMID 2478590.
Peltz GA, Grundy HO, Lebo RV, et al. (1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 1013–7. doi:10.1073/pnas.86.3.1013. PMID 2521732.
Scallon BJ, Scigliano E, Freedman VH, et al. (1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 5079–83. doi:10.1073/pnas.86.13.5079. PMID 2525780.
Ravetch JV, Perussia B (1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.". J. Exp. Med. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMID 2526846.
Simmons D, Seed B (1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.". Nature 333 (6173): 568–70. doi:10.1038/333568a0. PMID 2967436.
Indik ZK, Hunter S, Huang MM, et al. (1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.". Exp. Hematol. 22 (7): 599–606. PMID 7516890.
Detmers PA, Zhou D, Powell D, et al. (1995). "Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase.". J. Immunol. 155 (4): 2085–95. PMID 7543538.
Morcos M, Hänsch GM, Schönermark M, et al. (1995). "Human glomerular mesangial cells express CD16 and may be stimulated via this receptor.". Kidney Int. 46 (6): 1627–34. doi:10.1038/ki.1994.462. PMID 7700021.
Schumann G, Dasgupta JD (1995). "Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif.". Int. Immunol. 6 (9): 1383–92. doi:10.1093/intimm/6.9.1383. PMID 7819147.
Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.". J. Biol. Chem. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Altin JG, Pagler EB, Kinnear BF, Warren HS (1994). "Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells.". Immunol. Cell Biol. 72 (1): 87–96. doi:10.1038/icb.1994.13. PMID 8157290.
Pignata C, Prasad KV, Robertson MJ, et al. (1994). "Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells.". J. Immunol. 151 (12): 6794–800. PMID 8258691.
Cone JC, Lu Y, Trevillyan JM, et al. (1993). "Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells.". Eur. J. Immunol. 23 (10): 2488–97. doi:10.1002/eji.1830231017. PMID 8405050.
de Haas M, Koene HR, Kleijer M, et al. (1996). "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa.". J. Immunol. 156 (8): 3948–55. PMID 8609432.
Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (1997). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene.". J. Biol. Chem. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.
Koene HR, Kleijer M, Algra J, et al. (1997). "Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype.". Blood 90 (3): 1109–14. PMID 9242542.