Meclonazepam
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| Systematic (IUPAC) name | |
| (3S)-5-(2-chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 58662-84-3  |
| ATC code | None |
| PubChem | CID 3033985 |
| ChemSpider | 2298544  |
| UNII | RN43209SMA |
| ChEMBL | CHEMBL351821 |
| Chemical data | |
| Formula | C16H12ClN3O3 |
| Mol. mass | 329.74 |
| SMILES | eMolecules & PubChem |
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Meclonazepam[1] ((S)-3-methylclonazepam) was discovered by a team at Hoffmann-La Roche in the 1970s and is a drug which is a benzodiazepine derivative similar in structure to clonazepam.[2] It has sedative and anxiolytic actions like those of other benzodiazepines,[3] and also has anti-parasitic effects against the parasitic worm Schistosoma mansoni.[4]
[edit] See also
[edit] References
- ^ US Patent 4031078
- ^ The Lundbeck Institute. "Meclonazepam". Psychotropics. Lundbeck. http://www.psychotropics.dk/moleculeView/default.aspx?ID=1426&Catalogtype=A&ChapterID=1&Thissortorder=23.
- ^ Ansseau, M.; Doumont, A.; Thiry, D.; Von Frenckell, R.; Collard, J. (1985). "Initial study of methylclonazepam in generalized anxiety disorder. Evidence for greater power in the cross-over design". Psychopharmacology 87 (2): 130–135. PMID 3931136.
- ^ O'Boyle, C.; Lambe, R.; Darragh, A. (1985). "Central Effects in Man of the Novel Schistosomicidal Benzodiazepine Meclonazepam". European Journal of Clinical Pharmacology 29 (1): 105–108. PMID 4054198.
[edit] Further reading
- Abdul-Ghani, R. A.; Loutfy, N.; Hassan, A. (2009). "Experimentally promising antischistosomal drugs: A review of some drug candidates not reaching the clinical use". Parasitology Research 105 (4): 899–906. doi:10.1007/s00436-009-1546-2. PMID 19588166.
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