FZD8

Frizzled family receptor 8
PDB rendering based on 1ijy.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ijy
Identifiers
Symbols	FZD8; FZ-8; hFZ8
External IDs	OMIM: 606146 MGI: 108460 HomoloGene: 40606 IUPHAR: FZD8 GeneCards: FZD8 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • receptor binding • protein binding • Wnt-protein binding • PDZ domain binding • ubiquitin protein ligase binding • Wnt-activated receptor activity Cellular component • cytoplasm • Golgi apparatus • plasma membrane • integral to membrane • cell projection Biological process • negative regulation of transcription from RNA polymerase II promoter • vasculature development • axonogenesis • brain development • gonad development • embryo development • neuron differentiation • T cell differentiation in thymus • positive regulation of JUN kinase activity • positive regulation of transcription from RNA polymerase II promoter • canonical Wnt receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8325	14370
Ensembl	ENSG00000177283	ENSMUSG00000036904
UniProt	Q9H461	Q61091
RefSeq (mRNA)	NM_031866.2	NM_008058.2
RefSeq (protein)	NP_114072.1	NP_032084.2
Location (UCSC)	Chr 10: 35.93 – 35.93 Mb	Chr 18: 9.21 – 9.22 Mb
PubMed search	[1]	[2]

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3066.

Further reading

• Wang Y, Macke JP, Abella BS et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–4476. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21233/.
• Tamai K, Semenov M, Kato Y et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature 407 (6803): 530–535. doi:10.1038/35035117. PMID 11029007.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. //www.ncbi.nlm.nih.gov/pmc/articles/PMC310948/.
• Semënov MV, Tamai K, Brott BK et al. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771.
• Dann CE, Hsieh JC, Rattner A et al. (2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature 412 (6842): 86–90. doi:10.1038/35083601. PMID 11452312.
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–778. doi:10.1006/bbrc.2001.5430. PMID 11520064.
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–381. doi:10.1038/nature02462. PMID 15164054.
• Omoto S, Hayashi T, Kitahara K et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.