Serotonin antagonist

A serotonin antagonist is a drug used to inhibit the action at serotonin receptors.

Many of the most important medications of this class selectively act at the 5-HT3 receptor, and thus are known as 5-HT3 antagonists. However, other drugs such as ketanserin act upon other types of serotonin receptors.

Antagonists of the 5-HT_2A receptor are sometimes used as atypical antipsychotics, with the typical antipsychotics being purely dopamine antagonists.

'Ketanserine' blocks 5 HT2A,5 HT2C and alpha 1 receptors. 'Ondansetron,Dolansetron,Granisetron' are 5 HT3 receptor antagonist.they are efficacious in treating chemotherapy induced emesis. 'Clozapine' blocks 5 HT2A,5 HT2C,D4 receptors. 'Quetiapine' blocks 5 HT2A,5 HT1A,D1-2,HI,alpha 1 receptors. 'Methsergide' is 5 HT2A-2C antagonist and nonselective 5 HT 1 receptor blocker.it causes retrperitoneal fibrosis and mediastinal fibrosis. 'Cyproheptadine' blocks 5 HT2A, HI and it is a mild anticholinergic. 'Pizotifen' is a 5 HT2A-2C , H1 blocker and anticholinergic used for migraine prophylaxis

references Textbook of Pharmacology by H L Sharma

See also

• Serotonin receptor agonist

External links

• MeSH Serotonin+Antagonists
• MeSH list of agents 82012702