Carbinoxamine
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| Systematic (IUPAC) name | |
| 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N- dimethyl-ethanamine |
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| Clinical data | |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a606008 |
| Pregnancy cat. | C |
| Legal status | 4 mg is FDA approved |
| Routes | Oral: 4 mg tablet or 4 mg/5 mL liquid |
| Pharmacokinetic data | |
| Half-life | 10 to 20 hours |
| Identifiers | |
| CAS number | 486-16-8  |
| ATC code | R06AA08 |
| PubChem | CID 2564 |
| DrugBank | DB00748 |
| ChemSpider | 2466 |
| UNII | VED9E376NC |
| KEGG | D07617 |
| ChEBI | CHEBI:3398 |
| ChEMBL | CHEMBL864 |
| Chemical data | |
| Formula | C16H19ClN2O |
| Mol. mass | 290.788 g/mol |
| SMILES | eMolecules & PubChem |
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Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) antihistamine and anticholinergic. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is approved by the U.S. Food and Drug Administration (FDA) (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis.
Carbinoxamine is available in various countries around the world by itself, combined with decongestants such as pseudoephedrine, and also with other ingredients including paracetamol, aspirin, codeine hydrochloride &c.
In June 2006 the FDA announced that more than 120 branded pharmacy products containing carbinoxamine were being illegally marketed, and demanded they be removed from the marketplace. This action was precipitated by twenty-one reported deaths in children under the age of two who had been administered carbinoxamine-containing products. Despite the fact that the drug had not been studied in this age group, a multitude of OTC preparations containing carbinoxamine were being marketed for infants and toddlers. At present, all carbinoxamine-containing formulations are approved only for adults or children ages 3 or older.[1]
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