Dicycloverine
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| Systematic (IUPAC) name | |
| 2-(diethylamino)ethyl bi(cyclohexane)-1-carboxylate | |
| Clinical data | |
| Trade names | Byclomine, Bentyl, Dibent, Di-Spaz, Dilomine |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a684007 |
| Pregnancy cat. | B (US) |
| Legal status | ? |
| Pharmacokinetic data | |
| Protein binding | >99% |
| Half-life | 5 h |
| Identifiers | |
| CAS number | 77-19-0  |
| ATC code | A03AA07 |
| PubChem | CID 3042 |
| IUPHAR ligand | 355 |
| DrugBank | APRD00113 |
| ChemSpider | 2934 |
| UNII | 4KV4X8IF6V |
| KEGG | D07820 |
| ChEBI | CHEBI:4514 |
| ChEMBL | CHEMBL1123 |
| Chemical data | |
| Formula | C19H35NO2 |
| Mol. mass | 309.487 g/mol |
| SMILES | eMolecules & PubChem |
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Dicyclomine, also known as dicycloverine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.
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[edit] Medical uses
Dicyclomine is used to treat intestinal hypermotility, the symptoms of Irritable Bowel Syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.[1]
It is sold under various trade names.[2]
In the UK it is ingredient of a multi-ingredient preparation, together with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon.
It is also marketed as Meftal-SPAS containing mefenamic acid along with dicyclomine hydrochloride as an analgesic and antispasmodic.
[edit] Side effects
Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea and at higher doses, deliriant effects.[1] Recreational use of this drug for its anticholinergic effects has been rarely reported.[1][3]
[edit] Caution
Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.[1]
[edit] References
- ^ a b c d "Dicyclomine hydrochloride". Monograph. Drugs.com. http://www.drugs.com/monograph/dicyclomine-hydrochloride.html.
- ^ "Dicycloverine". International drug names. Drugs.com. http://www.drugs.com/international/dicycloverine.html.
- ^ Carlini E. A. (1993). "Preliminary note: dangerous use of anticholinergic drugs in Brazil". Drug and Alcohol Dependence 32 (1): 1–7. doi:10.1016/0376-8716(93)90016-J. PMID 8486081.
[edit] Notes
- Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
- Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4
[edit] External links
- "Dicyclomine". Medicine Net. http://www.medicinenet.com/dicyclomine/article.htm.
- "Dicyclomine". Medline Plus. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a684007.html.
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