Profenamine
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This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
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| Systematic (IUPAC) name | |
| N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ? |
| Pharmacokinetic data | |
| Protein binding | 93% |
| Half-life | 1 to 2 hours |
| Identifiers | |
| CAS number | 1094-08-2  |
| ATC code | N04AA05 |
| PubChem | CID 3290 |
| DrugBank | APRD00729 |
| ChemSpider | 3174 |
| UNII | O00T1I1VRN |
| ChEBI | CHEBI:313639 |
| ChEMBL | CHEMBL1206 |
| Chemical data | |
| Formula | C19H24N2S |
| Mol. mass | 312.473 g/mol |
| SMILES | eMolecules & PubChem |
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 (what is this?) (verify) |
Profenamine (Parsidol, Parsidan, Parkin), also known as ethopropazine, is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.
[edit] Chemistry
Ethopropazine, 10-(2-diethylaminopropyl) phenothiazine, is synthesized by alkylation of phenothiazine using 1-diethylamino-2-propylchloride in the presence of sodium amide.
- P. Carpentier, U.S. Patent 2,526,118 (1950).
- S.S. Berg, J.N. Ashley, U.S. Patent 2,607,773 (1952).
[edit] References
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