Denopamine
From Wikipedia, the free encyclopedia
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|---|---|
| Systematic (IUPAC) name | |
| 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | Oral |
| Identifiers | |
| CAS number | 71771-90-9 |
| ATC code | None |
| PubChem | CID 71754 |
| IUPHAR ligand | 534 |
| ChemSpider | 64795 |
| UNII | V5F60UPD8P  |
| KEGG | D02614 |
| Chemical data | |
| Formula | C18H23NO4 |
| Mol. mass | 317.37 g/mol |
| SMILES | eMolecules & PubChem |
Denopamine (INN) is a cardiotonic drug which acts as a Beta-1 adrenergic receptor agonist.[1] It is used in the treatment of angina[2] and may also have potential uses in the treatment of congestive heart failure[3] and for clearing pulmonary oedema.[4]
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[edit] References
- ^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002;18(7):407-13. PMID 12487507
- ^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. 2006 Apr 4;108(2):281-3. PMID 15913812
- ^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. 1998 Sep;32(3):808-15. doi:10.1016/S0735-1097(98)00314-3 PMID 9741531
- ^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. 2001 Feb;85(2):161-6. doi:10.1254/jjp.85.161 PMID 11286398
