Phenylethylidenehydrazine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| (1E)-1-ethylidene-2-phenylhydrazine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Pharmacokinetic data | |
| Half-life | ~12 hours |
| Identifiers | |
| CAS number | 935-07-9 |
| ATC code | None |
| PubChem | CID 6537404 |
| ChemSpider | 5020586 |
| Chemical data | |
| Formula | C8H10N2 |
| Mol. mass | 134.18 g/mol |
| SMILES | eMolecules & PubChem |
Phenylethylidenehydrazine (PEH) is an inhibitor of the enzyme GABA transaminase (GABA-T).[1][2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.[1] PEH likely plays a significant role in phenelzine's high efficacy in treating anxiety disorders.
[edit] See also
[edit] References
- ^ a b Parent MB, Master S, Kashlub S, Baker GB (January 2002). "Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum". Biochemical Pharmacology 63 (1): 57–64. doi:10.1016/S0006-2952(01)00856-5. PMID 11754874. http://linkinghub.elsevier.com/retrieve/pii/S0006295201008565.
- ^ Duffy S, Nguyen PV, Baker GB (2004). "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience 126 (2): 423–32. doi:10.1016/j.neuroscience.2004.03.007. PMID 15207360. http://linkinghub.elsevier.com/retrieve/pii/S0306452204001873.
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