Dacemazine
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| Systematic (IUPAC) name | |
| 2-dimethylamino-1-phenothiazin-10-ylethanone | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 518-61-6  |
| ATC code | None |
| PubChem | CID 68846 |
| ChemSpider | 62079  |
| UNII | verifiedrevid = 460112476 88D34UY0QI verifiedrevid = 460112476 |
| Chemical data | |
| Formula | C16H16N2OS |
| Mol. mass | 284.376 g/mol |
| SMILES | eMolecules & PubChem |
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Dacemazine (INN, also known as Ahistan and Histantine)[1] is a phenothiazine derivative which acts as an histamine antagonist at the H1 subtype. First described in 1951, it was never marketed as a drug on its own, although a combination of dacemazine and di-tert-butylnaphthalenesulfonate was sold as an antispasmodic and antitussive under the trade name Codopectyl.[1] It was also assessed as a possible anticancer drug.[2]
[edit] References
- ^ a b David J. Triggle; C. R. Ganellin, F. MacDonald (1996). Dictionary of Pharmacological Agents. 1. Boca Raton: Chapman & Hall/CRC. pp. p. 711. ISBN 0-412-46630-9. http://books.google.com/books?id=DeX7jgInYFMC&printsec=frontcover&source=gbs_summary_r&cad=0#PRA1-PA711,M1. Retrieved on August 2, 2008 through Google Book Search.
- ^ Karolyhazy G, Havas I, Jansco G, Kapas L, Sellei C. The anticarcinogenic effect of dimethylaminoacetyl-phentiazide (ahistan). Kiserletes Orvostudomany. 1952 Aug;4(4):260-2. PMID 13023855
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