EMD-386,088

EMD-386,088
Systematic (IUPAC) name
	5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	54635-62-0
ATC code	None
PubChem	CID 10131112
Chemical data
Formula	C14H14ClN2
Mol. mass	245.727 g/mol
SMILES	eMolecules & PubChem
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EMD-386,088 is an indole derivative which is used in scientific research. It acts as a potent and selective 5-HT₆ receptor agonist, with a K_i of 1 nM, a significantly higher affinity than older 5-HT₆ agonists such as EMDT, although it possesses moderate affinity for the 5-HT₃ receptor as well.^[1]

[edit] See also

^ Mattsson, C; Sonesson, C; Sandahl, A; Greiner, HE; Gassen, M; Plaschke, J; Leibrock, J; Böttcher, H (2005). "2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists". Bioorganic & medicinal chemistry letters 15 (19): 4230–4. doi:10.1016/j.bmcl.2005.06.067. PMID 16055331.