Benperidol
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| Systematic (IUPAC) name | |
| 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ℞-only (US) |
| Routes | Oral |
| Identifiers | |
| CAS number | 983-42-6  |
| ATC code | N05AD07 |
| PubChem | CID 16363 |
| ChemSpider | 15521  |
| UNII | 97O6X78C53 |
| ChEMBL | CHEMBL297302 |
| Chemical data | |
| Formula | C22H24FN3O2 |
| Mol. mass | 381.443 g/mol |
| SMILES | eMolecules & PubChem |
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Benperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol).[1]. It is an antipsychotic, which can be used for the treatment of schizophrenia[2], but it is primarily used to control antisocial hypersexual behaviour[3], and is sometimes prescribed to sex offenders as a condition of their parole, as an alternative to anti-androgen drugs such as cyproterone.[4]
Benperidol was discovered at Janssen Pharmaceutica in 1961.
[edit] References
- ^ Möller; Müller; Bandelow: Neuroleptika, 2001, WVG; ISBN 3-8047-1773-X (in German)
- ^ Bobon J, Collard J, Lecoq R, Benperidol and promazine: a "double blind" comparative study in mental geriatrics, Acta Neurol Belg. 1963 Oct;63:839-43.
- ^ British National Formulary (49th), British Medical Association 2005 p 183
- ^ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ., Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers, Journal of Endocrinology. 1975 Nov;67(2):179-88.
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