Levomethamphetamine
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| Systematic (IUPAC) name | |
| (R)-N-methyl-1-phenyl-propan-2-amine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | OTC |
| Routes | Nasal Inhalation |
| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Excretion | Renal |
| Identifiers | |
| CAS number | 537-46-2  |
| ATC code | ? |
| PubChem | CID 36604 |
| ChemSpider | 33634 |
| UNII | 44RAL3456C |
| KEGG | D02291 |
| Chemical data | |
| Formula | C10H15N |
| Mol. mass | 149.2 |
| SMILES | eMolecules & PubChem |
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Levomethamphetamine (other names include l-methamphetamine, levodesoxyephedrine, l-desoxyephedrine, levmetamfetamine), is the levorotary (R-enantiomer) of methamphetamine. Levomethamphetamine is a sympathomimetic vasoconstrictor which is the active ingredient used in some over-the-counter nasal decongestants including Vicks Vapor Inhaler.
[edit] Chemistry
Levomethamphetamine affects the sympathetic nervous system but has little activity in the central nervous system, so it is not thought to possess an addiction potential anywhere near that of racemic methamphetamine or dextromethamphetamine. Among its few physiological effects are the vasoconstriction that makes it useful for nasal decongestion.[1] The elimination half life of levomethamphetamine is between 13.3 and 15 hours.[2]
[edit] Side effects
When used as a nasal decongestant, levomethamphetamine has potential side effects resembling those of other sympathomimetic drugs used for the same purpose; these effects include hypertension (elevated blood pressure), tachycardia (rapid heart rate), nausea, stomach cramps, dizziness, headache, and tremors.[citation needed]
[edit] References
- ^ Nonprescription Products to Avoid With Hypertension by W. Steven Pray, PhD, DPh, Bernhardt Professor, Nonprescription Products and Devices, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, Oklahoma US Pharm. 2010;35(2):12-15. Posted 2/19/2010. Accessed via internet May 26, 2010. This new article incorporates the information formerly drawn from the article cited at the corresponding point in a previous version of this page, which article's former URL now forms a dead link.
- ^ Mendelson J, Uemura N, Harris D, et al. (October 2006). "Human pharmacology of the methamphetamine stereoisomers". Clin. Pharmacol. Ther. 80 (4): 403–20. doi:10.1016/j.clpt.2006.06.013. PMID 17015058.
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