Lorcainide

Lorcainide

Systematic (IUPAC) name
N-(4-chlorophenyl)-N-(1-isopropylpiperidin-4-yl)-2-phenylacetamide
Clinical data
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	78
Half-life	14.3 +/-3.7
Identifiers
CAS number	59729-31-6 N
ATC code	C01BC07
PubChem	CID 42884
ChemSpider	39116 Y
UNII	KGJ2T0N7IQ Y
KEGG	D08020 Y
ChEMBL	CHEMBL87543 Y
Chemical data
Formula	C22H27ClN2O
Mol. mass	370.915 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H27ClN2O/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18/h3-11,17,21H,12-16H2,1-2H3 Y Key:XHOJAWVAWFHGHL-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Lorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.

References

• Kesteloot H, Stroobandt R., Clinical experience with lorcainide (R 15 889), a new anti-arrhythmic drug, Arch Int Pharmacodyn Ther. 1977 Dec;230(2):225-34.
• Carmeliet E, Janssen PA, Marsboom R, Van Nueten JM, Xhonneux R., Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide, Arch Int Pharmacodyn Ther. 1978 Jan;231(1):104-30.