6-Fluoronorepinephrine
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| Systematic (IUPAC) name | |
| 4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Identifiers | |
| CAS number | 86820-21-5 |
| ATC code | None |
| PubChem | CID 1862 |
| IUPHAR ligand | 510 |
| ChemSpider | 1792  |
| ChEMBL | CHEMBL281232 |
| Chemical data | |
| Formula | C8H10FNO3 |
| Mol. mass | 187.17 g/mol |
| SMILES | eMolecules & PubChem |
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6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine.[1][1][2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.[2][3]
[edit] References
- ^ a b Kirk KL, Cantacuzene D, Nimitkitpaisan Y, et al. (December 1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry 22 (12): 1493–7. doi:10.1021/jm00198a012. PMID 231654.
- ^ a b c Stone EA, Lin Y, Sarfraz Y, Quartermain D (September 2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist". Brain Research 1291: 21–31. doi:10.1016/j.brainres.2009.07.049. PMID 19632210. http://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01470-X.
- ^ Stone EA, Grunewald GL, Lin Y, et al. (July 2003). "Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice". Synapse (New York, N.Y.) 49 (1): 67–76. doi:10.1002/syn.10212. PMID 12710017.
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