Talsupram
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| Systematic (IUPAC) name | |
| 3-(3,3-dimethyl-1-phenyl-2-benzothiophen-1-yl)-N-methyl-propan-1-amine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 21489-20-3 |
| ATC code | None |
| PubChem | CID 33014 |
| ChemSpider | 30557 |
| UNII | C6Z73MW6CR  |
| Chemical data | |
| Formula | C20H25NS |
| Mol. mass | 311.48 g/mol |
Talsupram (5-003) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.[1][2][3] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[4]
[edit] See also
[edit] References
- ^ Pawłowski L, Mazela H (1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology 88 (2): 240–6. doi:10.1007/BF00652248. PMID 3006113.
- ^ McConathy J, Owens MJ, Kilts CD, et al. (August 2004). "Synthesis and biological evaluation of [11Ctalopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter"]. Nuclear Medicine and Biology 31 (6): 705–18. doi:10.1016/j.nucmedbio.2003.05.001. PMID 15246361. http://linkinghub.elsevier.com/retrieve/pii/S096980510400054X.
- ^ Kelliher P, Kelly JP, Leonard BE, Sánchez C (April 2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology 28 (3): 332–47. doi:10.1016/S0306-4530(02)00026-4. PMID 12573300. http://linkinghub.elsevier.com/retrieve/pii/S0306453002000264.
- ^ http://www.healyprozac.com/Book/Introduction.doc
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