Dorzolamide

Dorzolamide

Systematic (IUPAC) name
(4S,6S)-2-ethylamino-4-methyl-5,5-dioxo- 5λ6,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
Clinical data
Trade names	Trusopt
AHFS/Drugs.com	monograph
MedlinePlus	a602022
Pregnancy cat.	C (US)
Legal status	℞-only (US)
Routes	Topical (eye drops)
Pharmacokinetic data
Protein binding	~33%
Half-life	4 months
Identifiers
CAS number	130693-82-2 N 120279-96-1
ATC code	S01EC03
PubChem	CID 5284549
DrugBank	DB00869
ChemSpider	4447604 Y
UNII	9JDX055TW1 Y
KEGG	D07871 N
ChEBI	CHEBI:4702 Y
ChEMBL	CHEMBL218490 Y
Chemical data
Formula	C10H16N2O4S3
Mol. mass	324.443 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 Y Key:IAVUPMFITXYVAF-XPUUQOCRSA-N Y
N (what is this?)  (verify)

Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent by decreasing the production of aqueous humour. It is optically applied in the form of eye drops. This drug, developed by Merck, was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design. Dorzolamide hydrochloride is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

The combination of dorzolamide with timolol is marketed under the trade name Cosopt.

External links

• Trusopt

Further reading

• Kubinyi H (1999). "Chance favors the prepared mind--from serendipity to rational drug design". J Recept Signal Transduct Res 19 (1–4): 15–39. doi:10.3109/10799899909036635. PMID 10071748. 
• Plummer C, MacKay E, Gelatt K (2006). "Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs". Vet Ophthalmol 9 (4): 245–9. doi:10.1111/j.1463-5224.2006.00469.x. PMID 16771760. 
• Grover S, Apushkin M, Fishman G (2006). "Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa". Am J Ophthalmol 141 (5): 850–8. doi:10.1016/j.ajo.2005.12.030. PMID 16546110. 
• Almeida G, Faria e Souza S (2006). "Effect of topical dorzolamide on rabbit central corneal thickness". Braz J Med Biol Res 39 (2): 277–81. doi:10.1590/S0100-879X2006000200015. PMID 16470316.