Piperoxan
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| 1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)piperidine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 59-39-2 135-87-5 (hydrochloride) |
| ATC code | None |
| PubChem | CID 6040 |
| ChemSpider | 5817 |
| UNII | 9ZCS27634Y  |
| ChEMBL | CHEMBL31836 |
| Chemical data | |
| Formula | C14H19NO2 |
| Mol. mass | 233.31 g/mol |
| SMILES | eMolecules & PubChem |
Piperoxan, also known as benodaine or benzodioxane, is a drug which was the very first antihistamine ever to be discovered.[1][2] It was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France.[1][2] Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933.[1][2][3] Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution,[4] and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.[1]
[edit] See also
[edit] References
- ^ a b c d Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1. http://books.google.com/books?id=IH4lPs6S1bMC&lpg=PA230&dq=piperoxan%20anthistamine&pg=PA230#v=onepage&q&f=false.
- ^ a b c Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9. http://books.google.com/books?id=R0W1ErpsQpkC&lpg=PA1010&dq=piperoxan%20anthistamine&pg=PA1010#v=onepage&q&f=false.
- ^ Fourneau, Ernest; Daniel Bovet (1933). "Recherches sur l'action sympathicolytique d'un nouveau dérivé du dioxane". Archives Internationales de Pharmacodynamie et de Thérapie 46: 178–91. ISSN 0003-9780.
- ^ "Daniel Bovet - Biography". http://nobelprize.org/nobel_prizes/medicine/laureates/1957/bovet-bio.html.
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