Mometasone furoate
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| Systematic (IUPAC) name | |
| (11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | C(US) |
| Legal status | Rx Only (US) |
| Routes | topical, nasal |
| Pharmacokinetic data | |
| Bioavailability | Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.[1] |
| Protein binding | 98% to 99% |
| Metabolism | hepatic |
| Half-life | 5.8 hours |
| Identifiers | |
| CAS number | 105102-22-5  83919-23-7 |
| ATC code | D07AC13 D07XC03, R01AD09, R03BA07 |
| PubChem | CID 441336 |
| DrugBank | APRD00289 |
| ChemSpider | 390091 |
| ChEBI | CHEBI:47564 |
| ChEMBL | CHEMBL1161 |
| Synonyms | (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate |
| Chemical data | |
| Formula | C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate |
| Mol. mass | 427.361 g/mol (Mometasone) 521.4 g/mol (Furoate) |
| SMILES | eMolecules & PubChem |
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Mometasone furoate (also referred to as mometasone) is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways.
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[edit] Uses, administration, and pharmacodynamics
Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma[2][3] for patients unresponsive to less potent corticosteroids, and penile phimosis.[4] In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.[5]
It reduces inflammation by causing several effects:[6][7][8]
- reversing the activation of inflammatory proteins
- activating the secretion of anti-inflammatory proteins
- stabilising cell membranes
- decreasing the influx of inflammatory cells
- the exact anti-inflammatory mechanism of action is unknown
[edit] Availability
Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet, Elosalic) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural and Progreś Laboratories markets it under mometAid.
It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.[9]
[edit] References
- ^ Zia R Tayab, Tom C Fardon, Daniel K C Lee, Kay Haggart, Lesley C McFarlane, Brian J Lipworth, and Günther Hochhaus (November 2007). "Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate". Br J Clin Pharmacol 64 (5): 698–705. doi:10.1111/j.1365-2125.2007.02919.x. PMC 2203259. PMID 17509041. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2203259.
- ^ Tan RA, Corren J (December 2008). "Mometasone furoate in the management of asthma: a review". Ther Clin Risk Manag 4 (6): 1201–8. PMC 2643101. PMID 19337427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2643101.
- ^ Bousquet J (May 2009). "Mometasone furoate: an effective anti-inflammatory with a well-defined safety and tolerability profile in the treatment of asthma". Int. J. Clin. Pract. 63 (5): 806–19. doi:10.1111/j.1742-1241.2009.02003.x. PMID 19392928. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1368-5031&date=2009&volume=63&issue=5&spage=806.
- ^ Khope S (March 2010). "Topical mometasone furoate for phimosis". Indian pediatr 47 (3): 282. PMID 20371899.
- ^ Williams D. What does potency actually mean for inhaled corticosteroids?. The Journal Of Asthma: Official Journal Of The Association For The Care Of Asthma [serial online]. July 2005;42(6):409-417. Available from: MEDLINE with Full Text, Ipswich, MA. Accessed October 25, 2011.
- ^ Product Information: NASONEX(R) nasal spray, mometasone furoate monohydrate nasal spray. Schering Corporation, Kenilworth, NJ, 2010.
- ^ Publishers, Jones and Bartlett (2009-07-15). Nurse's Drug Handbook 2010. p. 677. ISBN 9780763779009. http://books.google.com/?id=9b8JiegivA8C&pg=PA677
- ^ Mani S. Kavuru (2007). "ch. 9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 9781932610383. http://books.google.com/?id=Q1zF7xSRACIC
- ^ "Mometamax". Intervet USA. http://www.intervetusa.com/products/130_163343/productdetails_130_163679.aspx. Retrieved 19 June 2010.
[edit] External links
- Mometasone Furoate Oral Inhalation (MedlinePlus)
- Mometasone Furoate Nasal Inhalation (MedlinePlus)
- Nasonex Home page
- Asmanex Home page
- U.S. National Library of Medicine: Drug Information Portal - Mometasone furoate
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