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Cyanodothiepin

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Cyanodothiepin
Systematic (IUPAC) name
11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]thiepine-2-carbonitrile
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 90667-37-1
ATC code None
Chemical data
Formula C20H20N2S 
Mol. mass 320.45 g/mol
SMILES eMolecules & PubChem

Cyanodothiepin (BTS-56,424) is a drug of the tricyclic antidepressant (TCA) family which is a potent and highly selective (over norepinephrine and dopamine uptake) inhibitor of the reuptake of serotonin.[1][2][3] It also has moderate affinity for the mACh receptors and weak/negligible affinity for the α1-adrenergic, 5-HT2A, D1, and D2 receptors;[1][2][3] the H1 receptor has not been assayed,[3] but cyanodothiepin is less sedating than the related drug cianopramine, suggesting its antihistamine activity is not as pronounced as other TCAs.[1][3] Cyanodothiepin is active in the forced swimming test (FST), inferring that it may possess antidepressant properties in humans. However, it is only weakly active compared to cianopramine and imipramine in monoamine depletion-based tests of antidepressant potential.[1]

[edit] See also

[edit] References

  1. ^ a b c d Graham P, Lucosmbe, W, Roger Buckett (July 1993). "Pharmacology of cyanodothiepin (BTS 56 424), a selective 5-hydroxytryptamine reuptake inhibitor". Drug Development Research 29 (3): 235–248. doi:10.1002/ddr.430290311. http://onlinelibrary.wiley.com/doi/10.1002/ddr.430290311/abstract. 
  2. ^ a b Ernst Jucker (1 June 2000). Progress in Drug Research. Birkhäuser. pp. 79–80. ISBN 978-3-7643-6113-6. http://books.google.com/books?id=gwhdUGoO6KwC&pg=PA80. Retrieved 25 November 2011. 
  3. ^ a b c d Berend Olivier; I. van Wijngaarden; W. Soudijn (10 July 1997). Serotonin receptors and their ligands. Elsevier. pp. 332. ISBN 978-0-444-82041-9. http://books.google.com/books?id=lfo0hGqIex0C&pg=PA332. Retrieved 25 November 2011. 
Classes
Antidepressants
7-OH-Amoxapine • Amezepine • Amineptine • Amitriptyline • Amitriptylinoxide • Amoxapine • Aptazapine • Azepindole • Azipramine • Butriptyline • Cianopramine • Ciclazindol • Ciclopramine • Clomipramine • Cotriptyline • Cyanodothiepin • Demexiptiline • Depramine/Balipramine • Desipramine • Dibenzepin • Dimetacrine • Dosulepin/Dothiepin • Doxepin • Enprazepine • Esmirtazapine • Fluotracen • Hepzidine • Homopipramol • Imipramine • Imipraminoxide • Intriptyline • Iprindole • Ketipramine • Litracen • Lofepramine • Losindole • Loxapine • Maprotiline • Mariptiline • Mazindol • Melitracen • Metapramine • Mezepine • Mianserin • Mirtazapine • Naranol • Nitroxazepine • Nortriptyline • Noxiptiline • Octriptyline • Opipramol • Oxaprotiline • Pipofezine • Pirandamine • Propizepine • Protriptyline • Quinupramine • Setiptiline/Teciptiline • Tandamine • Tampramine • Tianeptine • Tienopramine • Trimipramine
Antihistamines
Antipsychotics
Acetophenazine • Amoxapine • Asenapine • Butaclamol • Butaperazine • Carphenazine • Carpipramine • Chlorpromazine • Chlorprothixene • Ciclindole • Clocapramine • Clomacran • Clorotepin • Clotiapine • Clozapine • Cyanothepin • Doclothepin • Docloxythepin • Erizepine • Flucindole • Flumezapine • Fluotracen • Flupentixol • Fluphenazine • Gevotroline • Homopipramol • Isofloxythepin • Levomepromazine/Methotrimeprazine • Loxapine • Maroxepin • Meperathiepin • Mesoridazine • Metitepine • Metoxepin • Mosapramine • Naranol • Octomethothepin • Olanzapine • Oxyclothepin • Oxyprothepin • Peradithiepin • Perathiepin • Perazine • Perphenazine • Periciazine • Piperacetazine • Pipotiazine • Piquindone • Prochlorperazine • Promazine • Prothipendyl • Quetiapine • Sulforidazine • Thiethylperazine • Thiopropazate • Thioridazine • Thiothixene • Tilozepine • Trifluoperazine • Triflupromazine • Trifluthepin • Zotepine • Zuclopenthixol
Others
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