RH-34

RH-34

Systematic (IUPAC) name
3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione
Clinical data
Pregnancy cat.	?
Legal status	Uncontrolled
Routes	?
Identifiers
CAS number	? Y
ATC code	None
PubChem	CID 10041987
Chemical data
Formula	C18H19N3O3
Mol. mass	325.361 g/mol
SMILES	eMolecules & PubChem
Y(what is this?)  (verify)

RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT_2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT_2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT_2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT_2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.

See also

• 5-MeO-NBpBrT
• Ketanserin