Pirenzepine

Pirenzepine

Systematic (IUPAC) name
11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	28797-61-7 Y
ATC code	A02BX03
PubChem	CID 4848
IUPHAR ligand	328
DrugBank	APRD00515
ChemSpider	4682 Y
UNII	3G0285N20N Y
KEGG	D08389 Y
ChEBI	CHEBI:8247 Y
ChEMBL	CHEMBL9967 Y
Chemical data
Formula	C19H21N5O2
Mol. mass	351.403 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26) Y Key:RMHMFHUVIITRHF-UHFFFAOYSA-N Y
N (what is this?)  (verify)

Pirenzepine (Gastrozepin) is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion. It has no effects on the brain and spinal cord as it cannot diffuse through the blood-brain barrier.

Pirenzepine has been investigated for use in myopia control.

See also

• AFDX-384