AL-37350A

AL-37350A
Systematic (IUPAC) name
	(S)-(+)-1-(2-Aminopropyl)-8,9-dihydropyrano[3,2-e]indole
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 10331436
IUPHAR ligand	160
ChemSpider	8506896
Chemical data
Formula	C14H18N2O
Mol. mass	230.305 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C14H18N2O/c1-9(15)7-10-8-16-12-4-5-13-11(14(10)12)3-2-6-17-13/h4-5,8-9,16H,2-3,6-7,15H2,1H3/t9-/m0/s1 ; Key:VVHJUSGIUWQPIT-VIFPVBQESA-N ;
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AL-37350A (4,5-DHP-AMT) is a tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT_2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT_2B and 5-HT_2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treament of glaucoma.^[1]

[edit] See also

[edit] References

^ May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry 46 (19): 4188–95. doi:10.1021/jm030205t. PMID 12954071.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

[pmid12954071-0] May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA (September 2003). "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry 46 (19): 4188–95. doi:10.1021/jm030205t. PMID 12954071.

[1]

Dec	JAN	Feb
	29
2011	2012	2013

AL-37350A

[edit] See also

[edit] References

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