Levobunolol

Levobunolol

Systematic (IUPAC) name
(S)-5-{[3-(tert-butylamino)-2-hydroxypropyl]oxy}-3,4-dihydronaphthalen-1(2H)-one
Clinical data
Trade names	Betagan
AHFS/Drugs.com	monograph
MedlinePlus	a686011
Pregnancy cat.	C
Legal status	℞-only (US)
Routes	Topical (eye drops)
Pharmacokinetic data
Half-life	20 hours
Identifiers
CAS number	47141-42-4 Y
ATC code	S01ED03
PubChem	CID 39468
DrugBank	APRD00165
ChemSpider	36089 Y
UNII	G6317AOI7K Y
KEGG	D08115 Y
ChEBI	CHEBI:6438 Y
ChEMBL	CHEMBL1201237 N
Chemical data
Formula	C17H25NO3
Mol. mass	291.385 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 Y Key:IXHBTMCLRNMKHZ-LBPRGKRZSA-N Y
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Levobunolol (AK-Beta, Liquifilm, Betegan) is a non-selective beta blocker. It is used topically to manage glaucoma.

External links

• Ishibashi T, Yokoi N, Kinoshita S (2003). "Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.". Cornea 22 (8): 709–15. doi:10.1097/00003226-200311000-00001. PMID 14576520. 
• Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). "[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]". Nippon Ganka Gakkai Zasshi 103 (7): 544–50. PMID 10443129. 
• Leung M, Grunwald J (1997). "Short-term effects of topical levobunolol on the human retinal circulation.". Eye 11 (3): 371–6. doi:10.1038/eye.1997.78. PMID 9373479.