Rauwolscine
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| 17α-hydroxy-20α-yohimban-16β-carboxylic acid methyl ester | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 131-03-3  6211-32-1 (HCl) |
| ATC code | None |
| PubChem | CID 643606 |
| IUPHAR ligand | 136 |
| ChemSpider | 558737  |
| ChEBI | CHEBI:48562 |
| ChEMBL | CHEMBL10347 |
| Chemical data | |
| Formula | C21H26N2O3 |
| Mol. mass | 354.44 g/mol |
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Rauwolscine, also known as isoyohimbine, α-yohimbine, and corynanthidine, is an alkaloid found in various species within the genera Rauwolfia and Pausinystalia (formerly known as Corynanthe).[1] It is a stereoisomer of yohimbine.[1] Rauwolscine is a central nervous system stimulant, a local anesthetic and a vague aphrodisiac.[1]
Rauwolscine acts predominantly as a α2-adrenergic receptor antagonist.[2] It has also been shown to function as a 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2B receptor antagonist.[3][4][5]
[edit] See also
[edit] References
- ^ a b c KOHLI JD, DE NN (June 1956). "Pharmacological action of rauwolscine". Nature 177 (4521): 1182. doi:10.1038/1771182a0. PMID 13334509.
- ^ Perry BD, U'Prichard DC (December 1981). "[3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors". European Journal of Pharmacology 76 (4): 461–4. doi:10.1016/0014-2999(81)90123-0. PMID 6276200.
- ^ Arthur JM, Casañas SJ, Raymond JR (June 1993). "Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors". Biochemical Pharmacology 45 (11): 2337–41. doi:10.1016/0006-2952(93)90208-E. PMID 8517875.
- ^ Kaumann AJ (June 1983). "Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 323 (2): 149–54. doi:10.1007/BF00634263. PMID 6136920.
- ^ Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL (January 1998). "[3HRauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor"]. Naunyn-Schmiedeberg's Archives of Pharmacology 357 (1): 17–24. doi:10.1007/PL00005133. PMID 9459568. http://link.springer.de/link/service/journals/00210/bibs/7357001/73570017.htm.
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